臺灣博碩士論文加值系統

本研究針對平面與管狀ePTFFE（拉伸性鐵氟龍，expanded Polytetrafluoroethylene）分別做不同實驗，片狀ePTFE進行化學改質的比較(sodium/naphthalene etchant與FluoroEtch)，並利用膠帶測試對片狀ePTFE試片的破壞程度，是否影響試片表面。針對管狀ePTFE部分則進行化學改質與大氣電漿改質處理之研究，以有別於處理片狀ePTFE的方法來處理管狀ePTFE，我們以管狀式自動轉體移動平台來進行電漿改質，並以測水滴接觸角與SEM、ESCA等方法來進行佐證。其中發現改質前的管狀ePTFE之水滴接觸角為130度，經過化學與電漿改質完後水滴接觸角降為25度，亦即經過處理後由疏水性變為親水性。經由ESCA分析得知管狀ePTFE經過化學處理後，其表面會產生去氟化反應而且大氣電漿可以打斷表面較弱的鍵結而形成官能基。經以上處理後的管狀ePTFE可達到活化與誘導效果，因此增加它與貼附性蛋白/胜肽的接枝效率，也因而促進人類臍帶靜脈內皮細胞(HUVECs)對其表面的貼附性。

In this study , several experiments ePTFE (expanded polytetrafluoroethylene) on flake and tubular were done to chemically modify ePTFE surface properties by sodium / naphthalene etchant and FluoroEtch. For tubular ePTFE alone, a special mechanism called tubular rotational movement platform was used to do the surface treatment. After all the experiments are conducted, three types of measurement contact angle, SEM and ESCA were taken to verify the quality of the surface treatment. We found that the contact angle of the tubular untreated ePTFE is 130 degrees, after chemical modification with plasma it reduces to 25 degrees, which indicates its surface has turned from hydrophobic into hydrophilic . After all of the surface treatments , we found that the bio-compatibility of ePTFE increased and the human umbilical vein endothelial cells (HUVECs) could attach well on the substrate surface .

致謝………………………………………………………………………I
摘要………………………………………………………...…………...III
Abstract…………………………………………..……………………. IV
目錄……………………………………………………………………...V
圖錄………………………………………………………………….. VIII
表錄………………………………………………………………….. XII
一、緒論…………………………………………………………………1
1.1前言……………………………………………………………..…1
1.1.1生醫材料之基本介紹………………………………..………1
1.1.2電漿應用與發展……………………………………..………4
1.2研究動機與目標………………………………………..…………5
1.3研究內容……………………………………………..……………6
二、ePTFE及大氣電漿簡介……………………………………………8
2.1拉伸性鐵氟龍(ePTFE) ……………………………..……………8
2.2 鈉蝕法(Sodium/naphthalene etchant) ……………..……………..8
2.3電漿表面改質技術.........................................................................11
2.3.1電漿簡介……………………………………………..…….11
2.3.2大氣電漿源…………………………………………..……..12
2.3.3大氣電漿基本特性……………………………………...….17
2.3.4電漿表面改質………………………………………...…….22
2.3.5電漿技術改質ePTFE………………………………..…….24
三、實驗架構與分析…………………………………………………..31
3.1實驗設計與架構……………..…………………………………31
3.1.1實驗架構……………………………………………………32
3.2實驗材料準備……..……………………………………………35
3.2.1平面ePTFE試片準備………………………………………35
3.2.2管狀ePTFE試片準備………………………...……………36
3.2.3鈉蝕法(Sodium/naphthalene etchant)化學系統……...……38
3.2.4鈉蝕法(Sodium/naphthalene etchant)溶液之製備………...41
3.2.5完成化學反應後，ePTFE試片之清洗-（標準清洗）……42
3.3 大氣電漿系統…………………………..………………………42
3.3.1常壓電漿設備系統…………………………………………42
3.4實驗設備………………………………………..……………….46
3.4.1接觸角量測儀………………………………………………46
3.4.2掃描式電子顯微鏡…………………………………………48
3.4.3 ESCA化學能量分析.……………………………………..49
四、實驗結果與歸納分析………………………………………………51
4.1 平面ePTFE………………………….…………………………51
4.1.1 sodium/naphthalene etchant and FluoroEtch……………….51
4.1.2膠帶測試……………………………………………………53
4.2管狀ePTFE………………………..……………………………54
4.2.1 管狀化學改質……………………………………………..54
4.2.2 管狀電漿改質……………………………………………..56
4.2.2.1掃描速率與距離對水滴接觸角之影響……………….56
4.2.2.2管狀式自動轉體移動平台……………………………58
4.2.2.3管狀式自動轉體移動平台與X、Y移動平台之關係…60
4.2.2.4 長型管狀ePTFE改質………………………………..61
4.3 ESCA鍵結變化與表面元素含量分析……………..………….63
4.4 SEM表面微結構觀察……………..…………………………...65
4.5內皮細胞(Huvecs)貼覆與增生……..…………………………..66
4.6流體實驗沖刷測試……………..……………………………….67
4.7動物實驗…………………………..……………………………69
五、結論與未來展望…………………………………………………...71
5.1結論…..…………………………………………………………71
5.2未來展望………………..………………………………………73
參考文獻………………………………………………………………..75
簡歷……………………………………………………………………..80

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